An honest, mechanism-first look at the DL185 dileucine + myHMB formula built for adults over 40 — what it does in the body, what it costs, and who should skip it.
Two ingredients, two jobs. Here's the three-part system Advanced Muscle Plus is built around.
Essential amino acids (like those in Advanced Amino Formula) supply the building blocks your body needs to make new muscle protein.
Dileucine, a bonded dipeptide of two leucine molecules, activates the mTOR pathway roughly 60% more strongly than plain leucine — the trigger that tells your body to actually build.
myHMB reduces muscle protein breakdown, protecting the mass you already have — even during low-activity or recovery periods.
No product is perfect. Here's the balanced view before you buy.
No — and they're actually complementary. Advanced Amino supplies the full set of essential amino acids (the raw material). Muscle Plus activates the muscle-building and preservation mechanisms with dileucine and HMB.
Full essential amino acid profile — the bricks.
Dileucine + myHMB — the trigger and the protection.
You're over 40, losing strength or recovering more slowly, and want a specific, research-backed formula instead of generic protein. Both ingredients act directly on muscle-building and muscle-preserving pathways, and it works best alongside resistance exercise.
You just want the cheapest option regardless of mechanism, or you won't pair it with any physical activity. It's a support system, not a substitute for training.
Cost per bottle is lowest on the 3-bottle order, which also unlocks free shipping. The 90-day guarantee lets you try it risk-free.
See Pricing & Availability →Many users report feeling stronger, firmer and recovering faster with consistent use. It's formulated with dileucine (DL185), which studies show raises muscle protein synthesis substantially more than standard leucine, plus myHMB, which reduces muscle breakdown. Results build over weeks and work best alongside some physical activity.
Dileucine is a more potent dipeptide form of leucine, the amino acid that activates the mTOR muscle-building pathway. Studies suggest it stimulates muscle protein synthesis roughly 60% more than plain leucine, which is why it's the core ingredient in this formula. Read the full breakdown in our What Is Dileucine? guide.
Advanced Amino supplies the full set of essential amino acids, the raw material for muscle building. Muscle Plus acts on the muscle-building and preservation mechanisms with dileucine and HMB. They're complementary, and many people over 40 use both together.
They work through entirely different mechanisms — creatine fuels energy output during high-intensity effort, dileucine triggers the muscle-building signal afterward. See our dileucine vs. creatine comparison for the full picture.
It works best when combined with some resistance activity, even a light strength workout. It can also help preserve muscle mass during low-activity periods, but it complements rather than replaces physical activity.
It's generally well tolerated. Some people may notice mild digestive discomfort when starting. Take it with a meal and check with your doctor first if you're on medication or have a health condition.