Worth it if you're over 40, losing strength or recovering slower, and you want a targeted, research-backed formula — 2g of dileucine (DL185) plus myHMB — rather than generic protein. The two ingredients genuinely target the build-and-preserve muscle pathways. Skip it if you want the cheapest scoop regardless of mechanism, or you won't pair it with any physical activity. It works best alongside some resistance movement.
What Advanced Muscle Plus actually is
Advanced Muscle Plus is a muscle-support supplement from Advanced Bionutritionals built around two serious, research-backed ingredients rather than a long filler list: Peptide DL185 (a patented dileucine dipeptide) and myHMB. It's aimed at adults over 40 fighting the slow, quiet loss of strength and muscle that comes with age — the kind that shows up as weaker grip, worse balance and slower recovery.
This is the more clinical sibling to Advanced Amino: where amino acids supply the raw material, Muscle Plus targets the muscle-building switch itself.
What works
- 2g dileucine (DL185) per serving — research-backed
- Dileucine beats standard leucine ~60% for synthesis
- myHMB protects against muscle breakdown
- Focused, clean-label formula — no filler
- Useful even when activity drops (e.g. recovery)
- 90-day money-back guarantee
What to know first
- Priced like a specialist, not a basic protein
- Works best paired with some resistance activity
- Mild digestive discomfort possible at first
- Not a substitute for protein intake
- Results build over weeks of consistent use
- Best value only on multi-bottle orders
How it works (the actual mechanism)
DL185 is a dileucine dipeptide — a more potent form of leucine, the amino acid that flips the muscle-building mTOR pathway "on." Research shows dileucine drives muscle protein synthesis substantially harder than ordinary leucine. myHMB works the other end: it reduces muscle protein breakdown, so you hold onto the muscle you have even during periods of low activity. Together it's a build-more-plus-lose-less strategy, which is exactly what matters after 40 when the body tilts toward loss.
The complaints nobody addresses — answered
"It's expensive for a muscle supplement."
True if you compare it to a tub of basic protein — but that's the wrong comparison. Dileucine and patented HMB are specialist ingredients that cost more than commodity amino acids. You're paying for the mechanism, not the scoop count.
"Do I still need to exercise?"
It helps most when paired with some resistance activity — even light strength work. It can preserve muscle during low-activity periods too, but it's a support, not a replacement for moving your body.
"Isn't this the same as your Advanced Amino?"
No — and they're actually complementary. Advanced Amino supplies the full set of essential amino acids (the raw materials). Muscle Plus targets the build-and-preserve switches with dileucine and HMB. Many people over 40 stack them: aminos for the building blocks, Muscle Plus for the signal.
Who it's for — and who should skip it
Buy it if you're over 40, losing strength or recovering slower, and you want a targeted, research-backed formula rather than generic protein. Skip it if you want the cheapest option regardless of mechanism, or you won't pair it with any physical activity at all.
Check today's price & multi-bottle discount
Lowest cost per bottle is on the 3-bottle order, which also unlocks free shipping. The 90-day guarantee lets you test it risk-free.
See Pricing & Availability →Frequently asked questions
Does Advanced Muscle Plus really work?
Many users report feeling stronger, firmer and recovering faster with consistent use. It is built on dileucine (DL185), which research shows raises muscle protein synthesis substantially more than standard leucine, plus myHMB, which reduces muscle breakdown. Results build over weeks and work best with some physical activity.
What is dileucine (DL185)?
Dileucine is a more potent dipeptide form of leucine, the amino acid that activates the mTOR muscle-building pathway. Studies suggest it drives muscle protein synthesis around 60% harder than ordinary leucine, which is why it is the centerpiece of this formula.
How is it different from Advanced Amino Formula?
Advanced Amino supplies the full set of essential amino acids, the raw materials for muscle. Muscle Plus targets the build-and-preserve switches with dileucine and HMB. They are complementary, and many people over 40 use both together.
Do I still need to exercise?
It works best paired with some resistance activity, even light strength work. It can also help preserve muscle during low-activity periods, but it supports rather than replaces physical activity.
Are there side effects?
It is generally well tolerated. Some people experience mild digestive discomfort when starting. Take it with a meal, and consult your doctor first if you take medication or have a health condition.